The fourth stage of the Tirreno-Adriatico takes the peloton from Tagliacozzo to Martinsicuro for 213 km and is the third consecutive day exceeding 200 kilometers. A stage that is certainly not straightforward, also because it immediately presents two classic Apennine climbs such as Ovindoli (km 36) and the Valico delle Capannelle (km 100.2).

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From the categorized climb begins the long descent towards Teramo and from here the peloton enters the final part of the stage which features a sequence of walls and "small walls". Riders will climb Castellalto (gradients around 12% for long stretches, km 164.3), Mosciano Sant'Angelo and 12 km from the finish the last categorized climb of the day, the Tortoreto wall via Badetta, which reaches 20% in the final section. Following this is a short descent before the 8 km along the seafront that lead to the finish line.